Studies
Hieronder vindt u een overzicht van onderzoek wat verricht wordt/is met biomateriaal van de AOCR.
Lopend prospectief onderzoek
Op dit moment zijn er nog geen prospectieve studies binnen de Archipelago gestart. Zodra deze studies van start gaan, vindt u hier informatie over de in- en exclusiecriteria en de deelnemende centra. Daarnaast zullen wij kort het studieprotocol toelichten.
Lopend retrospectief onderzoek
| Title study | Content | Principal Investigator (PI) | Affiliation of PI | Status |
|---|---|---|---|---|
| AOCR quality study | Quality control study of the first 1000 patients in the Archipelago of Ovarian Cancer Research | M.J. van de Vijver | Amsterdam UMC | In progress |
| EpiOvMet (Epigenetic profiling of Ovarian tumors and Metastases) | This study aims to determine whether distinct methylation profiles can differentiate between ovarian tumor subtypes and between primary ovarian carcinomas and gastrointestinal metastases, potentially aiding in precise diagnosis. | M.J. van de Vijver | Amsterdam UMC | Initiating |
| OVALINK (Ovarian Cancer and Endometrial Cancer: Linking Molecular Profiles) | The aim of this study is to molecularly profile type I OC using tissue samples from the Archipelago Biobank, exploring shared genetic alterations and pathogenic mechanisms with EC and correlate the genetic alterations with disease free and overall survival | Mieke L.G. ten Eikelder | RadboudUMC | Initiating |
Gepubliceerde onderzoeken
| Title aticle | Author(s) | Type of research | Histology tumor | Biomaterials from AOCR? | Link |
|---|---|---|---|---|---|
| Establishment of the Dutch Nationwide, Interdisciplinary Infrastructure and Biobank for Fundamental and Translational Ovarian Cancer Research: Archipelago of Ovarian Cancer Research | Zelisse et al. (2022); Archipelago of Ovarian Cancer Research Consortium | Study protocol | - | - | Pubmed Link |
| The Information Technology (IT) Infrastructure of the Multicenter Archipelago of Ovarian Cancer Research Biobank: A Potential Blueprint for Other Biobanks | Zelisse et al. (2024); Archipelago of Ovarian Cancer Research Consortium | Research infrastructure | - | - | Pubmed Link |
| Evaluation of the recently established Dutch nationwide Archipelago of Ovarian Cancer Research biobank | Zelisse et al. (2025); Archipelago of Ovarian Cancer Research Consortium | Evaluation study | High-grade serous carcinoma (n=284) Endometrioid carcinoma (n=26) Low-grade serous carcinoma (n=22) Clear cell carcinoma (n=21) Mucinous carcinoma (n=11) Carcinosarcoma (n=12) | Yes | Pubmed Link |